Welcome to the Malcolmson lab

Our Research

Organic methodology development and applications
Go to Umpolung Amine Synthesis

Umpolung Amine Synthesis

A traditional approach for the stereoselective synthesis of chiral amines via C–C bond formation employs the addition of nucleophiles to electrophilic imines. Although a number of elegant reactions have been developed

Go to Hydrofunctionalization


The enantioselective assembly of compounds bearing allylic stereogenic centers is an important objective in organic chemistry, both because of their utility in downstream synthesis and because of their prevalence in natural products and bioactive

Go to Hyperpolarization


The sensitivity of NMR/MRI methods is limited, due in part to the small thermal fractional magnetization of nuclei, resulting in a severe detection limit for abundant nuclei (e.g., 1H), a situation which is exacerbated for rarer isotopes, such as 13C and 15N


Pengfei Zhou

Postdoctoral Scientist
Year Joined: 2019
pengfei.zhou at duke.edu
Sichuan University (Ph.D. 2019)

Melanie Lee

6th Year Graduate Student
Year Affiliated: 2017
myoung.mi.lee at duke.edu
Seoul National University of Science and Technology