Research Articles

(reviews and patents appear separately at the end of this page)

22. “Copper-Catalyzed Diastereo-, Enantio-, and (Z)-Selective Aminoallylation of Ketones through Reductive Couplings of Azatrienes for the Synthesis of Allylic 1,2-Amino Tertiary Alcohols”

 

Jiaqi Zhu, Faraan Rahim, Pengfei Zhou, Annie Zhang, and Steven J. Malcolmson

Jiaqi Zhu

Graduate Student

Faraan Rahim

Undergraduate

Pengfei Zhou

Postdoctoral Scientist

Annie Zhang

Undergraduate

21. “Palladium-Catalyzed Regiodivergent Three-Component Alkenylamination of 1,3-Dienes with Alkyl and Aryl Amines”

 

Xiaoxiao Ma and Steven J. Malcolmson
This paper first appeared as a preprint:

Xiaoxiao Ma

Graduate Student

20. “A Diastereodivergent and Enantioselective Approach to syn- and anti-Diamines: Development of 2-Azatrienes for Cu-Catalyzed Reductive Couplings with Imines That Furnish Allylic Amines”

 

Pengfei Zhou, Xinxin Shao, and Steven J. Malcolmson
This paper first appeared as a preprint:
Highlighted in JACS Spotlight and featured in Organic Chemistry Highlights.

Pengfei Zhou

Postdoctoral Scientist

Xinxin Shao

Assistant Professor, Hangzhou Normal University

19. “Rational Ligand Choice Extends the SABRE Substrate Scope”

 

Johannes F. P. Colell*, Angus W. J. Logan*, Zijian, Zhou, Jacob R. Lindale, Raul Laasner, Roman V. Shchepin, Eduard Y. Chekmenev, Volker Blum, Warren S. Warren, Steven J. Malcolmson, and Thomas Theis

*These authors contributed equally to this work.

Gus Logan

Postdoctoral Scientist

18. “Enantioselective Construction of Quaternary Stereogenic Centers by the Addition of an Acyl Anion Equivalent to 1,3-Dienes”

 

Nathan J. Adamson, Sangjune Park, Pengfei Zhou, Andrew L. Nguyen and Steven J. Malcolmson

Nathan Adamson

Graduate Student

Sangjune Park

Postdoctoral Scientist

Pengfei Zhou

Postdoctoral Scientist

17. “Enantio- and Diastereoselective Synthesis of Homoallylic α-Trifluoromethyl Amines by Catalytic Hydroalkylation of Dienes”

 

Chibueze I. Onyeagusi, Xinxin Shao and Steven J. Malcolmson
This paper first appeared as a preprint:

Chibueze Onyeagusi

Graduate Student

Xinxin Shao

Postdoctoral Scientist

16. “Catalytic Enantio- and Diastereoselective Cyclopropanation of 2-Azadienes for the Synthesis of Aminocyclopropanes Bearing Quaternary Carbon Stereogenic Centers”

 

Xinxin Shao and Steven J. Malcolmson

Xinxin Shao

Postdoctoral Scientist

15. “Preparation of Chiral Allenes through Pd-Catalyzed Intermolecular Hydroamination of Conjugated Enynes: Enantioselective Synthesis Enabled by Catalyst Design”

 

Nathan J. Adamson, Haleh Jeddi and Steven J. Malcolmson

Nathan Adamson

Graduate Student

14. “Brønsted Acid and Pd–PHOX Dual-Catalysed Enantioselective Addition of Activated C-Pronucleophiles to Internal Dienes”

 

Sangjune Park, Nathan J. Adamson and Steven J. Malcolmson

Sangjune Park

Postdoctoral Scientist

Nathan Adamson

Graduate Student

13. “Palladium-Catalyzed Synthesis of α-Trifluoromethyl Benzylic Amines via Fluoroarylation of gem-Difluoro-2-azadienes Enabled by Phosphine-Catalyzed Formation of an Azaallyl–Silver Intermediate”

 

Paige E. Daniel*, Chibueze I. Onyeagusi*, Anthony A. Ribeiro, Kangnan Li and Steven J. Malcolmson

*These authors contributed equally to this work.

Paige Daniel

Graduate Student

Chibueze Onyeagusi

Graduate Student

Kangnan Li

Graduate Student

12. “Development and Mechanistic Investigations of Enantioselective Pd-Catalyzed Intermolecular Hydroaminations of Internal Dienes”

 

Sangjune Park and Steven J. Malcolmson

Sangjune Park

Postdoctoral Scientist

11. “Enantioselective Synthesis of anti-1,2-Diamines by Cu-Catalyzed Reductive Couplings of Azadienes with Aldimines and Ketimines”

 

Xinxin Shao, Kangnan Li and Steven J. Malcolmson
Highlighted in Synfacts and featured in Organic Chemistry Highlights.

Xinxin Shao

Postdoctoral Scientist

Kangnan Li

Graduate Student

10. “Enantioselective Intermolecular Pd-Catalyzed Hydroalkylation of Acyclic 1,3-Dienes with Activated Pronucleophiles”

 

Nathan J. Adamson, Katie C. E. Wilbur and Steven J. Malcolmson

Nathan Adamson

Graduate Student

Katie Wilbur

Undergraduate Student

9. “2-Azadienes as Reagents for Preparing Chiral Amines: Synthesis of 1,2-Amino Tertiary Alcohols by Cu-Catalyzed Enantioselective Reductive Couplings with Ketones”

 

Kangnan Li*, Xinxin Shao*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

Highlighted in Synform, Synfacts and featured in Organic Chemistry Highlights.

Kangnan Li

Graduate Student

Xinxin Shao

Postdoctoral Scientist

Luke Tseng

Undergraduate Student

8. “Diastereoselective and Enantiospecific Synthesis of 1,3-Diamines via 2-Azaallyl Anion Benzylic Ring-Opening of Aziridines”

 

Kangnan Li*, Alexandria E. Weber*, Luke Tseng, and Steven J. Malcolmson

*These authors contributed equally to this work.

Kangnan Li

Graduate Student

Allie Weber

Graduate Student

Luke Tseng

Undergraduate Student

7. “Diazirines as Potential Molecular Imaging Tags: Probing the Requirements for Efficient and Long-Lived SABRE-Induced Hyperpolarization”

 

Kun Shen,* Angus W. J. Logan,* Johannes F. P. Colell,* Junu Bae, Gerardo X. Ortiz, Jr., Thomas Theis, Warren S. Warren, Steven J. Malcolmson, and Qiu Wang

*These authors contributed equally to this work.

Very Important Paper featured on the journal cover here

Gus Logan

Postdoctoral Scientist

6. “Umpolung Synthesis of 1,3-Amino Alcohols: Stereoselective Addition of 2-Azaallyl Anions to Epoxides”

 

Paige E. Daniel, Alexandria E. Weber, Steven J. Malcolmson

Org. Lett., 2017, 19, 3490−3493.

Paige Daniel

Graduate Student

Allie Weber

Graduate Student

 

5. “Direct Hyperpolarization of Nitrogen-15 in Aqueous Media with Parahydrogen in Reversible Exchange”

 

Johannes F. P. Colell, Meike Emondts, Angus W. J. Logan, Kun Shen, Junu Bae, Roman V. Shchepin, Gerardo X. OrtizJr., Peter Spannring, Qiu Wang, Steven J. Malcolmson, Eduard Y. Chekmenev, Martin C. Feiters, Floris P. J. T. Rutjes, Bernhard Blümich, Thomas Theis, and Warren S. Warren

Gus Logan

Postdoctoral Scientist

4. “Enantioselective Intermolecular Addition of Aliphatic Amines to Acyclic Dienes with a Pd–PHOX Catalyst”

 

Nathan J. Adamson, Ethan Hull and Steven J. Malcolmson

Nathan Adamson

Graduate Student

Ethan Hull

Graduate Student

3. “Generalizing, Extending, and Maximizing Nitrogen-15 Hyperpolarization Induced by Parahydrogen in Reversible Exchange”

 

Johannes F. P. Colell, Angus W. J. Logan, Zijian Zhou, Roman V. Shchepin, Danila A. Barskiy, Gerardo X. Ortiz Jr., Qiu Wang, Steven J. Malcolmson, Eduard Y. Chekmenev, Warren S. Warren, Thomas Theis

Gus Logan

Postdoctoral Scientist

2. “Hyperpolarization of Nitrogen–15 Schiff Bases by Reversible Exchange Catalysis with para–Hydrogen”

 

Angus W. J. Logan, Thomas Theis, Johannes F. P. Colell, Warren S. Warren, Steven J. Malcolmson

Gus Logan

Postdoctoral Scientist

1. “Direct and Cost-Efficient Hyperpolarization of Long-lived Nuclear Spin States on Universal 15N2-Diazirine Molecular Tags”

 

Thomas Theis, Gerardo X. Ortiz, Angus W.J. Logan, Kevin E. Claytor, Yesu Feng, William P. Huhn, Volker Blum, Steven J. Malcolmson, Eduard Y. Chekmenev, Qiu Wang, Warren S. Warren

Gus Logan

Postdoctoral Scientist


Work Prior to Duke

Postdoctoral

3. “The Posttranslational Modification Cascade to the Thiopeptide Berninamycin Generates Linear Forms and Altered Macrocyclic Scaffolds”

Steven J. Malcolmson, Travis S. Young, J. Graham Ruby, Peter Skewes-Cox, Christopher T. Walsh

2. “Dihydrophenylalanine: a Prephenate-Derived Photorhabdus luminescens Antibiotic and Intermediate in Dihydrostilbene Biosynthesis”

Jason M. Crawford, Sarah A. Mahlstedt, Steven J. Malcolmson, Jon Clardy, Christopher T. Walsh

1. “Nine Enzymes are Required for Assembly of the Pacidamycin Group of Peptidyl Nucleoside Antibiotics”

Wenjun Zhang, Ioanna Ntai, Megan L. Bolla, Steven J. Malcolmson, Daniel Kahne, Neil L. Kelleher, Christopher T. Walsh


Graduate

6. “Bipyridine Adducts of Molybdenum Imido Alkylidene and Imido Alkylidyne Complexes”

Alejandro G. Lichtscheidl, Victor W. L. Ng, Peter Müller, Michael K. Takase, Richard R. Schrock, Steven J. Malcolmson, Simon J. Meek, Bo Li, Elizabeth T. Kiesewetter, Amir H. Hoveyda

5. “The Significance of Degenerate Processes to Enantioselective Olefin Metathesis Reactions Promoted by Stereogenic-at-Mo Complexes”

Simon J. Meek, Steven J. Malcolmson, Bo Li, Richard R. Schrock, Amir H. Hoveyda

4. “Design and Stereoselective Preparation of a New Class of Chiral Olefin Metathesis Catalysts and Application to Enantioselective Synthesis of Quebrachamine. Catalyst Development Inspired by Natural Product Synthesis“

Elizabeth S. Sattely, Simon J. Meek, Steven J. Malcolmson, Richard R. Schrock, Amir H. Hoveyda

3. “Enantioselective Synthesis of P-Stereogenic Phosphinates and Phosphine Oxides by Mo-Catalyzed Asymmetric Ring-Closing Metathesis”

James Stephen Harvey, Steven J. Malcolmson, Katherine S. Dunne, Simon J. Meek, Amber L. Thompson, Richard R. Schrock, Amir H. Hoveyda, Véronique Gouverneur

2. “Highly Efficient Molybdenum-Based Catalysts for Enantioselective Alkene Metathesis”

Steven J. Malcolmson*, Simon J. Meek*, Elizabeth S. Sattely, Richard R. Schrock, Amir H. Hoveyda
*These authors contributed equally

1. “Enantioselective Synthesis of Cyclic Enol Ethers and All-Carbon Quaternary Stereogenic Centers Through Catalytic Asymmetric Ring-Closing Metathesis”

Ai-Lan Lee, Steven J. Malcolmson, Alessandra Puglisi, Richard R. Schrock, Amir H. Hoveyda

Reviews and Book Chapters

13. “Shattering the Mirror with Copper Catalysis”

 

12. “Oxazole, 2-[2-[bis[3,5-bis(trifluoromethyl)phenyl]phosphino]phenyl]-4-(1,1-dimethylethyl)-4,5-dihydro”

 

Nathan J. Adamson and Steven J. Malcolmson

11. “Racing Against Unwanted Isomerization”

 

10. “Strategies for the Catalytic Enantioselective Synthesis of α-Trifluoromethyl Amines”

 

Chibueze I. Onyeagusi and Steven J. Malcolmson

Chibueze Onyeagusi

Graduate Student

9. “Catalytic Enantio- and Regioselective Addition of Nucleophiles in the Intermolecular Hydrofunctionalization of 1,3-Dienes”

 

Nathan J. Adamson and Steven J. Malcolmson

Nathan Adamson

Graduate Student

8. “2-Azadienes as Enamine Umpolung Synthons for the Preparation of Chiral Amines”

 

Steven J. Malcolmson, Kangnan Li and Xinxin Shao

Kangnan Li

Graduate Student

Xinxin Shao

Postdoctoral Scientist

7. “Dimethoxymethylsilane”

 

Xinxin Shao and Steven J. Malcolmson
(Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, Bode, Charette, Rovis, Eds.; DOI: 10.1002/047084289X.rn02262); Wiley-VCH: Weinheim, 2019.

6. “Catalyst-Controlled Stereoselective Olefin Metathesis”

Amir H. Hoveyda, R. Kashif M. Khan, Sebastian Torker and Steven J. Malcolmson
(Handbook of Olefin Metathesis, Vol. 2, Second Edition, Grubbs, Wenzel, O’Leary, Khosravi, Eds.; 503–562); Wiley-VCH: Weinheim, 2015.

5. “Three Ring Posttranslational Circuses: Insertion of Oxazoles, Thiazoles, and Pyridines into Protein-Derived Frameworks”

Christopher T. Walsh, Steven J. Malcolmson and Travis S. Young

4. “Catalytic Enantioselective Olefin Metathesis and Natural Product Synthesis”

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek and Adil R. Zhugralin
(Metathesis in Natural Product Synthesis: Strategies, Substrates and Catalysts; Cossy, Arseniyadis, Meyer, Eds.; 343–348); Wiley-VCH: Weinheim, 2010.

3. “Catalytic Enantioselective Olefin Metathesis in Natural Product Synthesis. Chiral Metal-Based Complexes that Deliver High Enantioselectivity and More“

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek and Adil R. Zhugralin

2. “Catalytic Enantioselective Olefin Metathesis Reactions”

Amir H. Hoveyda, Steven J. Malcolmson, Simon J. Meek and Adil R. Zhugralin
(Catalytic Asymmetric Synthesis, Third Edition; Ojima, Ed.; 739–770); Wiley-VCH: Weinheim, 2010.

1. “Molybdenum,[(S)-3,3′-bis(1,1-dimethylethyl)-5,5′,6,6′-tetramethyl[1,1′-biphenyl]-2,2′-diolato(2-)-kO,kO’]-2-methyl-2-phenylpropylidene)-[tricyclo1decan-1-aminato(2-)]”

Steven J. Malcolmson, Amir H. Hoveyda and Richard R. Schrock
(Encyclopedia of Reagents for Organic Synthesis, Second Edition; Paquette, Crich, Fuchs, Molander, Eds.; 1765–1768); Wiley-VCH: Weinheim, 2009.


Patents

2. “Complexes for Use in Metathesis Reactions”

Amir, H. Hoveyda, Richard R. Schrock, Simon, J. Meek, Steven, J. Malcolmson, Elizabeth T. Kiesewetter
US Patent No. 20120302710 A1; Publication Date: November 29, 2012.

1. “Catalysts for Metathesis Reactions Including Enantioselective Olefin Metathesis, and Related Methods”

Steven J. Malcolmson, Amir H. Hoveyda, Simon J. Meek, Richard R. Schrock
US Patent No. 9687834; Issue Date: June 27, 2017.